Rank 2006 Company Country Revenue in 2006 (USD millions) R&D in 2006 (USD millions) Net income/ (loss) in 2006 (USD millions) Employees in 20061 Amgen USA 14,268.0 3,366.0 2,950.0 20,1002 Genentech USA 9,284.0 1,773.0 2,113.0 10,5333 Genzyme USA 3,187.0 650.0 -16.8 9,000+4 UCB Belgium 3,169.6 772.6 461.1 8,4775 Gilead Sciences USA 3,026.1 383.9 -1,190.0 7,5756 Serono Switzerland 2,804.9 560.5 735.4 4,7757 Biogen Idec USA 2,683.0 718.4 217.5 3,7508 CSL Australia 2,148.3 119.1 86.8 2,8959 Cephalon USA 1,764.1 403.4 144.8 2,51510 MedImmune USA 1,276.8 448.9 48.7 2,35911 Celgene USA 898.9 258.6 69.0 1,86412 Abraxis BioScience USA 765.5 96.9 -46.9 1,73413 Actelion Switzerland 754.6 169.0 192.4 1,55014 ImClone Systems USA 677.8 112.1 370.7 1,28715 Elan Ireland 560.4 215.9 -267.3 1,25216 Amylin Pharmaceuticals USA 510.9 222.1 -218.9 1,10017 Millennium Pharmaceuticals USA 486.8 318.2 -44.0 1,07318 PDL BioPharma USA 414.8 260.7 -130.0 99319 OSI Pharmaceuticals USA 375.7 176.7 -582.2 96220 MGI Pharma USA 342.8 100.1 -40.2 94721 Pharmion USA 238.6 70.1 -91.0 79322 Nektar Therapeutics USA 217.7 149.4 -154.8 77023 Vertex Pharmaceuticals USA 216.4 371.7 -206.9 76024 Biocon Limited India 200.3 30.5 43.5 183825 Cubist Pharmaceuticals USA 194.7 57.4 -0.4 74626 Enzon Pharmaceuticals USA 185.7 43.5 21.3 72227 QLT Canada 175.1 56.4 -101.6 65328 ViroPharma USA 167.2 19.2 66.7 65129 Alkermes USA 166.6 89.1 3.8 61730 Crucell Netherlands 165.3 84.9 -110.0 61131 United Therapeutics USA 159.6 57.6 74.0 58532 LifeCell USA 141.7 16.5 20.5 57333 Ligand Pharmaceuticals USA 141.0 41.9 -31.7 54034 Myriad Genetics USA 114.3 83.8 -38.2 51135 Exelixis USA 98.7 185.5 -101.5 50036 Cangene Canada 96.8 22.1 11.6 49837 InterMune USA 90.8 103.8 -107.2 49238 Nabi Biopharmaceuticals USA 89.9 37.6 -58.7 48739 BioMarin Pharmaceutical USA 84.2 66.7 -28.5 41740 Lexicon Pharmaceuticals USA 72.8 106.7 -54.3 41041 Progenics Pharmaceuticals USA 69.9 61.7 -21.6 41042 Innogenetics Belgium 67.5 32.1 -31.5 37143 Idenix Pharmaceuticals USA 67.4 96.1 -75.1 35944 MorphoSys Germany 66.6 21.9 7.6 33645 Omrix Biopharmaceuticals USA 63.8 3.4 23.1 33546 Regeneron Pharmaceuticals USA 63.4 137.1 -102.3 32347 Acambis UK 57.0 68.2 -30.4 28548 Tanox USA 56.1 53.4 -2.6 28549 ViaCell USA 54.4 14.0 -21.0 28250 Indevus Pharmaceuticals USA 50.5 43.2 -50.6 27951 Medarex USA 48.6 194.5 -181.7 27752 NPS Pharmaceuticals USA 48.5 68.4 -112.7 27653 Monogram Biosciences USA 48.0 19.0 -38.7 27454 Oscient Pharmaceuticals USA 46.2 12.4 -78.5 26755 Array BioPharma USA 45.0 33.4 -39.6 26356 AEterna Zentaris Canada 41.4 28.7 33.4 26057 IsoTis Switzerland 40.7 7.7 -18.5 25558 Enzo Biochem USA 39.8 7.9 -15.7 25559 CuraGen USA 39.6 58.5 -59.8 25460 Neurocrine Biosciences USA 39.2 97.7 -107.2 25461 MediGene Germany 38.4 26.7 -8.7 24862 Life Therapeutics Australia 37.6 0.1 -31.2 24563 Inspire Pharmaceuticals USA 37.1 42.5 -42.1 23864 CV Therapeutics USA 36.8 135.3 -274.3 23365 Cerus USA 35.6 29.5 -4.8 20866 SciClone Pharmaceuticals USA 32.7 14.1 0.7 19767 ImmunoGen USA 32.1 40.9 -17.8 19768 Protherics UK 30.9 11.8 -16.5 19669 Arena Pharmaceuticals USA 30.6 103.4 -88.3 19570 Vernalis UK 30.1 71.7 -78.2 19271 Bavarian Nordic Denmark 29.5 19.9 -27.1 19172 Xoma USA 29.5 52.1 -51.8 18973 GPC Biotech Germany 28.5 81.3 -80.4 18074 Micromet USA 27.6 28.3 0.0 17175 Targacept USA 27.5 21.8 -1.2 17076 Carrington Laboratories USA 27.4 5.8 -7.6 16677 Acorda Therapeutics USA 27.4 12.1 -60.0 15878 Anika Therapeutics USA 26.8 3.6 4.6 15679 Human Genome Sciences USA 25.8 209.2 -251.2 15180 Dusa Pharmaceuticals USA 25.6 6.2 -31.3 15081 ZymoGenetics USA 25.4 128.5 -130.0 15082 Maxygen USA 25.0 49.1 -16.5 14783 Isis Pharmaceuticals USA 24.5 80.6 -45.9 13384 Genmab Denmark 23.9 90.6 -77.4 12885 Bioniche Life Sciences Canada 23.9 11.6 -1.0 12686 Vitrolife Sweden 23.2 3.3 2.1 12487 Coley Pharmaceutical Group USA 20.2 40.9 -29.4 12288 Palatin Technologies USA 19.7 41.0 -29.0 11689 Encysive Pharmaceuticals USA 19.0 64.4 -109.3 10990 GenVec USA 18.9 29.6 -19.3 9591 Medivir Group Sweden 18.8 39.7 -29.7 8892 Peptech Australia 18.7 4.6 3.8 8593 Ambrilia Biopharma Canada 17.4 8.3 -2.1 8594 Cytogen USA 17.3 7.3 -15.1 8595 Replidyne USA 16.0 38.3 -34.6 7996 Sinovac Biotech China 15.4 0.3 -0.7 6797 Trimeris USA 15.2 18.3